Texas Mesothelioma Fact Sheet
While mesothelioma is a problem in all states, the specific incident rate for Texas is 0.9 / 100,000. This is below the average rate of 1.1 / 100,000. Click on the tabs below to find mesothelioma and asbestos research in TX, recent TX mesothelioma-related court cases, mesothelioma specialists in TX and potential asbestos hotspots in Texas.
Texas Mesothelioma Info
By clicking on the above tabs, you will find information on mesothelioma specific to the state of Texas
Texas Research and Clinical Trials
This is a partial list of scientific or medical grants in your state for research into mesothelioma and related illnesses.
Texas Doctors and Hospitals
This is a partial list of hospitals and physicians that reportedly treat mesothelioma patients in your state.
Texas Cases
This is a partial list of relevant court cases on mesothelioma in your state.
Disclaimer: Inclusion on this directory does not constitute endorsement by Cancer Monthly, Inc. All physicians who appear in this section do so based on their own expression of interest in the fields of mesothelioma treatment. Cancer Monthly, Inc. has not verified the competence, professional credentials, business practices or validity of the expressed interests of these physicians. Cancer Monthly makes no recommendation of any physician on this list and makes no suggestion that any such physician will cure or prevent any disease. Those consulting a physician on this list should approach the consultation exactly as they would with any other unknown physician.
This is a partial list of scientific or medical grants in your state for research into mesothelioma and related illnesses.
Texas Doctors and Hospitals
This is a partial list of hospitals and physicians that reportedly treat mesothelioma patients in your state.
Texas Cases
This is a partial list of relevant court cases on mesothelioma in your state.
Disclaimer: Inclusion on this directory does not constitute endorsement by Cancer Monthly, Inc. All physicians who appear in this section do so based on their own expression of interest in the fields of mesothelioma treatment. Cancer Monthly, Inc. has not verified the competence, professional credentials, business practices or validity of the expressed interests of these physicians. Cancer Monthly makes no recommendation of any physician on this list and makes no suggestion that any such physician will cure or prevent any disease. Those consulting a physician on this list should approach the consultation exactly as they would with any other unknown physician.
In re E.I. du Pont de Nemours & Co.
NO. 08-0625, SUPREME COURT OF TEXAS, July 3, 2009, Opinion Delivered
NO. 08-0625, SUPREME COURT OF TEXAS, July 3, 2009, Opinion Delivered
In re GE Co.
NO. 07-0195, SUPREME COURT OF TEXAS, November 14, 2007, Argued, December 5, 2008, Opinion Delivered
NO. 07-0195, SUPREME COURT OF TEXAS, November 14, 2007, Argued, December 5, 2008, Opinion Delivered
In re Global Sante Fe Corp.
No. 07-0040, SUPREME COURT OF TEXAS, January 16, 2008, Argued, December 5, 2008, Opinion Delivered
No. 07-0040, SUPREME COURT OF TEXAS, January 16, 2008, Argued, December 5, 2008, Opinion Delivered
Borg-Warner Corp. v. Flores
NO. 05-0189, SUPREME COURT OF TEXAS, September 29, 2006, Argued , June 8, 2007, Opinion Delivered
NO. 05-0189, SUPREME COURT OF TEXAS, September 29, 2006, Argued , June 8, 2007, Opinion Delivered
Hallco Tex., Inc. v. McMullen County
NO. 02-1176 , SUPREME COURT OF TEXAS, January 4, 2005, Argued , December 29, 2006, Opinion Delivered
NO. 02-1176 , SUPREME COURT OF TEXAS, January 4, 2005, Argued , December 29, 2006, Opinion Delivered
In re Van Waters & Rogers, Inc.
NO. 03-0777 , SUPREME COURT OF TEXAS, September 3, 2004, Delivered
NO. 03-0777 , SUPREME COURT OF TEXAS, September 3, 2004, Delivered
Pustejovsky v. Rapid-American Corp.
NO. 98-1128, SUPREME COURT OF TEXAS, September 8, 1999, Argued , November 30, 2000, Opinion Issued
NO. 98-1128, SUPREME COURT OF TEXAS, September 8, 1999, Argued , November 30, 2000, Opinion Issued
Todd Shipyards Corp. v. Perez
NO. 99-0697, SUPREME COURT OF TEXAS, May 18, 2000, Delivered
NO. 99-0697, SUPREME COURT OF TEXAS, May 18, 2000, Delivered
Temple-Inland Prods. Corp. v. Carter
No. 97-0592, SUPREME COURT OF TEXAS, October 21, 1998, Argued , April 29, 1999, Delivered
No. 97-0592, SUPREME COURT OF TEXAS, October 21, 1998, Argued , April 29, 1999, Delivered
Union Carbide Corp. v. Smith
NO. 01-08-00641-CV, COURT OF APPEALS OF TEXAS, FIRST DISTRICT, HOUSTON, October 1, 2009, Opinion Issued
NO. 01-08-00641-CV, COURT OF APPEALS OF TEXAS, FIRST DISTRICT, HOUSTON, October 1, 2009, Opinion Issued
Hospitals and Cancer Centers
University of Texas-MD Anderson Cancer Center
1515 Holcombe Blvd Unit 432
Houston, TX
713.792.6363
Physicians
Department Of Clinical Investigation
University of Texas, MD Anderson Cancer Center
1515 Holcombe Blvd., P.O. Box 39
Houston, TX 77030
(713) 792-7959
Paul Mansfield, M.D.
M.D. Anderson Cancer Center
1515 Holcombe Blvd Ste 444
Houston, TX 77030
(713) 792-6161
University of Texas-MD Anderson Cancer Center
1515 Holcombe Blvd Unit 432
Houston, TX
713.792.6363
Physicians
Department Of Clinical Investigation
University of Texas, MD Anderson Cancer Center
1515 Holcombe Blvd., P.O. Box 39
Houston, TX 77030
(713) 792-7959
Paul Mansfield, M.D.
M.D. Anderson Cancer Center
1515 Holcombe Blvd Ste 444
Houston, TX 77030
(713) 792-6161
| City | Site |
|
Celotex Corp | |
| Abilene |
Abilene Hospital Dyess Air force Base |
| Alvin |
Amoco Chocolate Bayou |
| Amarillo |
Amarillo City Barn Amarillo Helium Amarillo Incinerator Amarillo Public Schools Amarillo Smelter Amarillo Trade School American Lead & Zinc Asarco Copper Asarco Harrington Station Nicholas Station NORAD OK Asbestos Co Pantex RJH Apartments Smelter Plant St Anthony Sulphur Plant Texaco Refinery |
| Andrews |
Williams Electric |
| Angleton |
Right Motor Company |
| Arlington |
Quality Inn Six Flags Mall |
| ARP |
Baker Tank-ARP |
| Aurora |
Texas Gulf Chemical Plant |
| Austin |
Wight Engineering |
| Bastrop |
International Paper Company |
| Bay City |
Celanese Plant Chemical Plant Cornet Rice Mill Nuclear Plant |
| Bayport |
Oxyrene Chemical Plant Retszlof Chemical |
| Baytown |
Aamco Brown & Rood Cedar Bayou Power Plant Chevron Chemical Chevron Oil Chevron Gulf |
| Baytown |
Esso Refinery Exxon Chemical |
| Baytown |
Gulf Oil Refinery Humble Exxon Mobay Chemical PH Robinson Power Plant Shell Oil Standard Oil |
| Beaumont |
Beaumont Works Bethlehem Steel Dupont Chemical Gulf Oil Magnolia Petroleum Mobil Oil Shell Oil Sinclair Oil Sun Oil Union 76 Refinery |
| Big Spring |
Carbon Plant |
| Big Spring |
Cosden Oil & Chemical Cosden Petrofina Refinery |
| Big Springs |
Ammonia Facility Big Springs High School Fina Refinery |
| Bishop |
Celanese Chemical Celanese Plant Champion Petroleum |
| Borger |
Carbon Black Co Co-Polymer Rubber & Chemical Phil Tex Philblack Plant Phillips Carbon Black Plant Phillips Petroleum Phillips Plains Plant Phillips Refinery Phillips Refinery Phillips Rubber Plant Standard Asbestos |
| Brownsville |
Amoco Chemical Standard Brownsville Hospital Carthage Hyrocol Plant Chartage-Hydrocol City of Brownsville Power Plant Marathon Oil Union Carbide |
| Bryan |
Bryan Station Power Plant |
| Bunavista |
Copolymer Rubber Plant Phillips Petroleum Plains Plant |
| Byer City |
Phillips North Plant |
| Cactus |
Phillips Petroleum |
| Calvert City |
BF Goodrich |
| Cedar Bayou |
Spencer Chemical-Gulf Oil Plant |
| Center |
Parker Brothers Car Dealership |
| Channelview |
Arco Chemical Plant Cargill Fertilizer Plant Chevron Oil Refinery |
| Cherry Point |
Standard Oil |
| Chocolate Bayou |
American Oil Refinery Amoco Chemical Dow Chemical Monsanto Chemical Phillips Petroleum |
| Clarksville |
Clarksville Base Clarksville Hospital |
| Clear Lake |
NASA |
| Cleveland |
Diamond Shamrock |
| Clute |
Ross Motor Company |
| College Station |
Texas A&M University |
| Comanche |
Nabisco |
| Commerce |
Talley Automotive |
| Commerce City |
Total Petroleum Refinery |
| Conroe |
Texaco Refinery |
| Cordell |
Whitco |
| Corpus Christi |
Bedford Construction Company C.C. Plumbing & Heating CCPC Celanese Chemical Central Power and Light Dispatching Chevron Oil Refinery Coastal States Refinery Corn Products Co. Intl. Corpus Christi Plumbing & Heating Corpus Christi Shipyard Hoechst Celanese Nueces Bay Power Station Reynolds Corpus Southern Alkale Southwest Oil Refinery Sun Tide Refinery Valeo Water Street Station |
| Crane |
Phillips Petroleum |
| Crockett |
Firestone |
| Cypress |
Daniel Valve |
| Daingerfield |
Lone Star Steel |
| Dalhart |
Phillips Helium Plant |
| Dallas |
Armored Motor Co AT&T Dallas Works Plant Austin Bridge Baker Hotel Baylor Hospital City Of Dallas Citywide Heating and Air Cooks Machinery Dallas ISD Dallas Morning News Dallas Plumbing DFW Airport Frymire Engineering General Electric Mobil Building Mrs. Bairds North Lake Plant Owens Corning Ware Painters Union #53 Palace Theatre Parkdale Plant Parkland Hospital Presbyterian Hospital Quality Inn Redmond Plaza Republic Bank Building Reunion Arena Reunion Hotel Sheraton SMU St Paul Hosp State Farm Tempo Heating & Air Travelers Insurance Company United Industries Company United Tile Company VAMC Verson All Steel Mfg co Ward Bros Plumbing |
| Deer Park |
Big Three Gas Brown & Root Celanese Chemical Crown Chemical Diamond Shamrock Refinery Dupont Chemical Ethel Corp Hoechst Celanese Occidental Chemical Phillips Refinery Quantium Rohm & Haas Sam Berton Power Plant Sam Berton Power Plant Shell Chemical Shell Oil & Refinery Shell Refinery Union Carbide Upjohn chemical US Industries |
| Denison |
Johns-Manville |
| Denton |
Chick Spec. Co Texas Women's University University of North Texas |
| Denver City |
Shell Oil Shell Plant |
| Desoto |
Cory-Joslins Macnsons |
| Dimmitt |
Anstart EL Cor Chemical Good Pasture Fertilizer Plant |
| Dumas |
American Zinc Smelter Diamond Shamrock Refinery Natural Gas Pipeline Phillips Petroleum Phillips Refinery Phillips Refinery Shamrock |
| Eagle Lake |
Arco Chemical Plant |
| Earth |
Plant X |
| Edna |
B&R Compressor Station |
| El Paso |
Airway Blvd Art Craft Tile Co Asarco Chevron Refinery Darbyshire Steel El Paso Electric Co El Paso Gas Newman Power House Pecos HS Phelps Dodge Providence Hospital Rio Grande Power Standard Chemical Refinery Standard Oil Sun Power Hospital Texaco Refinery Thomas Hospital |
| Elk |
Trading House Power Plant |
| Elsa |
Elsa Canning |
| Ennis |
Southern Pacific Railroad |
| Evadale |
East TX Paper Mill |
| Evandale |
Owens Illinois Paper Company |
| Fairfield |
Fairfield Powerhouse |
| Flower Bluff |
CP&L Power Plant Flower Bluff Power Station |
| Fort Bliss |
Fort Bliss |
| Fort Hood |
Civil Service |
| Fort Worth |
Carswell AFB |
| Freeport |
BASE Dow Chemical Dupont Chemical Ethel Corp Monsanto Chemical Rhone Pulene Shintech |
| Ft. Worth |
Commerce Building Dixon Jenkins Plant General Dynamics |
| Gainesville |
Armco Plant |
| Galveston |
Gulf Oil King Boilerworks Naval Shipyard Standard Dredging Co Todd Shipyard |
| Glen Rose |
Brown & Root Glen Rose Squaw Valley Plant |
| Gonzales |
Marathon Oil Texaco Refinery |
| Grand Prairie |
Chance Voight Aircraft |
| Green Bayou |
B & R Pipe Mill |
| Greenville |
Auto Care by Jerry Auto Doc Caldwell Covering City of Greenville Crawford Smith Repair Firestone Judson Textile Mill Toyota House |
| Gulf Port |
VA Hospital |
| Hamlin |
Celotex Manufacturing Plant |
| Harbor Island |
Texaco Refinery |
| Harlingen |
Air Force Base-Harlingen Sun Valley Mall Valley Baptist Hospital |
| Henderson |
Martin Lake Plant Spencer Chemical-Gulf Oil Plant |
| Hereford |
Ford Motor Company |
| Hillsboro |
Keasbey & Mattison Plant |
| Houston |
Amoco Chemical Amoco Oil Refinery Anchor Packing AO Smith Pipe Plant Anheuser Busch Brewery Arco Refinery Arco Sinclair Armco Sheffield Steel Armco Sheffield Steel Astrodome Stadium Bear Creek Golf Course Clubhouse Brown & Root Brown & Root Brown & Todd Shipyard Brown Shipyard Buck Jones Sandblasting Budweiser Brewery Burbank Elementary Campbell Roofing Cameron Iron Carnation Plant Cashmere Garden High School Celanese Champion Simpson Paper Mill Charter Oil Chevron Oil Refinery ( Green Bayou) Chicago Bridge & Iron Citizen's Bank Cleco Air Tools Consolidated Chemical Continental Airport Crown Chemical Daniel Valve Diamond Shamrock Refinery Dixel Manufacturing Dow Chemical Dupont Chemical Eagle Insulation Exxon Refinery Fiberglass Insulations Gavis St. Power Plant Goodyear Plant Green Bayou Power Gulf Oil Refinery Hewitt Machine Houston Power & Light Humble Bldg Intercontinental Airport Johnson Space Center Lone Star Heat Maxwell House Plant Monsanto Chemical Mrs. Bairds M and J Valve Nabisco NASA Palm Center Pennzoil Building Penwalt Chemical Petrotex |
| Houston |
Phillips 66 |
| Houston |
Phillips Refinery R&P Machine Shop R&P Machine Shop Rice University Roman Hause Chemical Sam Houston High School Seing Loin Roofing Sheffield Steel Mill Shell building Shell Refinery Shelter W Green Shortcut to Sun Tide Refinery Signal Oil Sinclair Copper Southland Paper Mill Stauffer Chemical Sun Tide Refinery T.H. Wharton Power Plant Tennaco Refinery Tennessee Gas Building Tetrahydrofuran Plant Texaco Refinery Texas Children's Hospital Texas Petrochem Todd Shipyard Tony Marin Body Shop Union Carbide Water Treatment Plant West Printing Co White Motor Company Yard & Bloodworth |
| Huntsville |
Sam Houston University |
| Ingleside |
Reynolds Metal |
| Kennedy |
CNR Lease Service Seaboard Oil co |
| Kermit |
Burns Electric |
| Kermit |
Gulf Oil Shell Oil |
| Kerrville |
Ramada Inn |
| Killeen |
Fort Hood |
| Kingsville |
Communications Bldg Hoechst Celanese |
| LaGrange |
Calloway Textile Mill |
| LaPorte |
Air Products Bayport Chemical Complex Big 3 Oxygen & Nitrogen Plant Dupont Chemical Dupont Chemical Retszlof Chemical Rohm & Haas Shell Oil Refinery Tennaco Refinery Union Carbide Upjohn Dow Chemical US Industries |
| Laredo |
Laredo Power Plant US Air Force Base |
| League City |
Webster Power Plant |
| Lone Star |
Lone Star Steel |
| Long view |
Standard Tool |
| Longview |
ADV Ross-Roy Green Combustion Eng. Eastman Kodak International Paper Company R.G. Letourneau Trinity Industries |
| Lubbock |
Reese Air Force Base Sound Photo Southwestern Power Service SPS Texas Tech University |
| Lufkin |
Champion International |
| Marshall |
B. W. Karbo Pipeline Texas & Pacific Railroad |
| Maryneal |
Chemical Plant |
| Meade-Kingsport |
Rust Engineering |
| Mesquite |
Dallas Works Plant TU Electric |
| Midland |
Bank Building Midland Cosland Gas Refinery Paragon Midland Safety Building Twin Tower Bank Building |
| Monahans |
Sealey Smith Plant |
| Monahans |
Texas Utilities |
| Monahans |
TU Electric |
| Mount Pleasant |
American Petro Fina Monticello Plant |
| Nacogdoches |
SFA University |
| Nederland |
Pure Oil Refinery Sun Oil Refinery |
| Odessa |
A & B Plumbing Bowie Junior High Burns Electric Butane Diane Plant El Paso Chemical Foreman Electric Odessa College Odessa School District Portland Cement Plant Ref Chem Corp Rexall Plant Rexene Plastics Rexene Polymor Rubber Plant Shell Oil Shell Refinery Star Insulation StarAdair Insulation Texas Instruments University of Texas University of Texas University of Texas Permian Basin Webb Woodworks |
| Old Ocean |
Pan American-Aroco Product Plant Pan American-Aroco Product Plant |
| Old Ocean |
Phillips 66 |
| Old Ocean |
Phillips Refinery |
| Orange |
American Bridge Atlantic Reserve Fleet BF Goodrich Chevron Gulf Consolidated Shipyard Dupont Chemical Echo Plant Fina Refinery Firestone Levingston Shipyard OI Paper Mill Owens Illinois Paper Company Phillips Carbon Sabine Industries Shell Oil Refinery Spencer Chemical-Gulf Oil Plant |
| Owentown |
Pittsburgh Corning Roadmaster |
| Pampa |
Cabot Plant Celanese Phillips Petroleum |
| Panhandle |
Pan-Tex Plant |
| Paris |
Babcock & Wilcox Campbell's Soup Plant |
| Pasadena |
A.G. Monday Plastic Plant Air Products Al Wheeler Arco Refinery Arco Refinery Arco Sinclair Bayshore Hospital Celanese Chemical Champion Simpson Paper Mill Crown Chemical Refinery Crown Chemical Petroleum Crown-Central Refinery Deerwater Power Plant Diamond Shamrock Dixie Chemical Dupont Chemical Ethel Corp Exxon Refinery Goodyear Plant Hoechst Celanese Humble Exxon Marathon Oil Mobil Chemical Parson Construction Pasadena School District Phillips 66 Phillips 66 Phillips Petroleum Rohm & Haas Rohm- Haas Shell Oil Sol-Tex Tennaco |
| Pasadena-Deer Park |
Texas All-Kyls |
| Pecos |
Brandon Hotel |
| Phillips |
Phillips Petroleum Rice Plant |
| Plains |
Plains Plant |
| Point Comfort |
Alcoa Plant Formosa Plastics |
| Port Angeles |
Texaco |
| Port Aransas Pass |
Stillman Trans |
| Port Arthur |
Atlantic Refinery Carbon Black Plant Chevron Continental Can Co Fina Refinery Great Lakes Carbon Gulf Oil Power Plant St Mary's Hospital Texaco Chemical Plant Texaco Refinery |
| Port Lavaca |
Alcoa Atar Facility Dechert Exxon Joslin Power Station Union Carbide |
| Port Neches |
Dupont Chemical Independent Refinery Jefferson Chemical Neches Butane Products Petro Gas Port Neches Pure Oil Refinery Texaco Chemical Plant Texaco Refinery Texas US Chemical |
| Port Nueces |
BF Goodrich |
| Powerhouse |
University of Texas At Austin |
| Premont |
Petrochemical Plant |
| Refugio |
B&R Compressor Station Compressor Station |
| Richardson |
Texas Instruments TI Manufacturer |
| Rio Grande City |
Rincon Gas Compression Station |
| Rockdale |
Alcoa Plant |
| Rusk |
Rusk State Hospital |
| San Angelo |
Goodfellow AFB Johnson & Johnson San Angelo School District Shannon Hospital |
| San Antonio |
Beckwith Eng. C5 Building Calaveras Power Plant City Public Service JT Deeley Power Plant Lackland Air Force Base Lackland Power Plant Leon Creek Power Plant Mission Road Power Plant Pearl Brewing San Antonio Power Plant Southern Ice & cold Storage Texaco Oil Refinery Texas Culture Building Tutle Power US AA building US Hospital Victor Bauning Power Plant Water Power Division WB Tuttle Power Plant |
| San Patrick |
Reynolds Metals Company |
| Sanford |
Phillips Petroleum |
| Seadrift |
Brown & Root Union Carbide Vistron |
| Senora |
Trentham Corp |
| Sequin |
AT&T Building |
| Sheldon |
Southland Paper Mill |
| Sherman |
Capital Product Kaiser Aluminum Texas Instruments Wilson Jones Hospital |
| Sherman-Denison |
RSI |
| Skelleytown |
Cabot Plant |
| Slaton |
Santa Fe Railroad |
| Sugarland |
Nalco Chemical |
| Sulphur Springs |
Price Ford Motor |
| Sundown |
Arco Chemical Plant |
| Sunray |
Shamrock Refinery |
| Sweeney |
Amoco Refinery Phillips Petroleum Phillips Refinery |
| Sweetwater |
Sweetwater School District United States Gypsum |
| Taylor |
Bahan Textile |
| Texarkana |
Cooper Tire & Rubber Company Globe Union Johnson Control Red River Army Depot |
| Texas City |
Amoco Texas City American Oil Amoco Chemical Amoco Refinery Arthur G. McKee Construction Bechtel Refinery Bethel GAF Plant Marathon Oil Monsanto Chemical Pan American Refinery Philbra Republic Oil Texas City Sterling Chemical Tin Processing Corp Union Carbide Union Republic Plant Weftner Power Plant White Coast |
| Tomball |
S-R Wintergreen Wessell Manufacturing |
| Tyler |
Block Metal General Electric Trine Plant Kelly Springfield Tire Southern Aluminum Sterling Faucet Tyler Lee HS Tyler Pipe Western Foundry |
| Van Horn |
EL Cor Chemical |
| Vicksburg |
Spencer Chemical-Gulf Oil Plant |
| Victoria |
CP&L Electric Plant Dupont Chemical Powerhouse Town Plaza mall Union Carbide Victoria Works |
| Vidor |
Champion Paper Mill Owens Illinois Paper Company |
| Waco |
Libby Owens Ford Glass Plant Owens Illinois Trading House Creek Power Plant |
| Weatherford |
3M Plant |
| Webster |
Webster Power Plant |
| Weimar |
Utex |
| White Oak |
Cherokee Street |
| Wichita Falls |
City National Bank Fina Refinery Ponds Laundry Sheppard AFB Wichita Falls Auditorium YMCA |
| Winnsboro |
Getty Oil Refinery |
| Woodville |
S&T Fabricating |
Research
Smythe, W Roy. Targeting Bcl-xl Expression In Mesothelioma
Grant: 1R01CA098545-01A1
Grant: 1R01CA098545-01A1
Abstract: DESCRIPTION (provided by applicant): Malignant mesothelioma is an example of a solid tumor extremely unresponsive to conventional therapy, with few patients surviving for more than 12 months regardless of treatment. We postulate that this treatment unresponsiveness is due to apoptosis resistance. BCL-XL is an anti-apoptotic member of the BCL-2 protein family, and is over-expressed in mesothelioma. Attenuated expression of other anti-apoptotic proteins and normal pro-apoptotic protein expression is noted in this tumor. Data from our laboratory suggests that constitutive transcriptional activation of the bcl-xl gene is responsible for protein over-expression. We have demonstrated bcl-xl down-regulation in human mesothelioma cells at the protein and mRNA level by both antisense oligonucleotide and full-length adenoviral antisense constructs leads to apoptotic human cell death in vitro. Down-regulation of bcl-xl also sensitizes mesothelioma cells to subsequent in vitro chemotherapy exposure leading to additive or synergistic cellular death. Pilot studies evaluating in vivo down-regulation of bcl-xl utilizing an adenoviral vector antisense construct or antisense oligonucleotides demonstrate inhibition of mesothelioma tumor growth. These experimental results suggest the following hypotheses: (1) bcl-xl expression is abnormal in mesothelioma due to up-regulation of constitutive transcriptional activity, (2) bcl-xl over-expression is in part responsible for mesothelioma clinical treatment resistance, (3) down-regulation of bcl-xl expression will lead to a bcl-2 family protein "imbalance" favoring apoptosis, (4) in vivo administration of bcl-xl antisense oligonucleotides will lead to BCL-XL down-regulation and apoptotic death of mesothelioma tumor cells, and (5) down-regulation of BCL-XL expression in vivo will sensitize mesothelioma tumor cells to conventional treatments such as chemotherapy and ionizing radiation. We will test the hypotheses regarding constitutive transcriptional activation by evaluation of the known transcriptional pathways and promoter function for bcl-xl. In vivo treatment hypotheses will be tested by use of established animal xenograft treatment models of mesothelioma. Our goals are to understand the mechanism of transcriptional up-regulation of the bcl-xl gene in this tumor, and to find a more effective clinical treatment for malignant mesothelioma. A more complete knowledge of bcl-xl constitutive up-regulation mechanisms could be of therapeutic import for a number of solid tumors that have a similar bcl-2 family phenotype. Upstream targets regulating bcl-xl expression for use in future therapeutic paradigms may be identified.
Tags: Bcl2 Gene /protein, Apoptosis, Gene Expression, Genetic Transcription, Mesothelioma Genetic Regulation, Neoplasm /cancer Genetics, Neoplastic Growth, Oligonucleotide Clinical Research, Gel Mobility Shift Assay, Human Tissue, Immunocytochemistry, Laboratory Mouse, Polymerase Chain Reaction, Tissue /cell Culture, Western Blotting
Tags: Bcl2 Gene /protein, Apoptosis, Gene Expression, Genetic Transcription, Mesothelioma Genetic Regulation, Neoplasm /cancer Genetics, Neoplastic Growth, Oligonucleotide Clinical Research, Gel Mobility Shift Assay, Human Tissue, Immunocytochemistry, Laboratory Mouse, Polymerase Chain Reaction, Tissue /cell Culture, Western Blotting
- Followup Grant: 7R01CA098545-02
- Followup Grant: 5R01CA098545-03
- Followup Grant: 5R01CA098545-04
Walker, Cheryl L. Wilm's Tumor Suppressor Gene In Masothelioma
Grant: 1R01ES006658-01
Grant: 1R01ES006658-01
Abstract: Mesothelioma is an asbestos associated tumor arising from mesothelial cells
that line the body cavities.
Although the etiology of asbestos induced mesothelioma has been well
described, very little is known about the molecular alterations that cause
these tumors. Our lack of knowledge regarding the molecular events that
cause mesothelioma has hampered efforts to identify alternative fibers that
can be used as safe asbestos substitutes and has contributed to a
diagnostic dilemma in the identification of these tumors. The long range
goal of this research is to understand how asbestos fibers transform
mesothelial cells. To achieve this goal, the general approach is to
identify molecular alterations that occur in transformed mesothelial cells
and elucidate the mechanism by which asbestos fibers caused these
alterations. The proposed studies are designed to determine the role of
the Wilms' tumor (WT-1) suppressor gene in normal and malignant mesothelial
cells. Specific Aims are to 1) Determine the expression pattern of the WT
1 gene in normal and transformed rat mesothelial cells. The expression of
the 4 splice variants of WT-1 in normal and transformed mesothelial cells
will be examined by PCR to identify differences in gene processing between
normal and transformed cells. Using in situ hybridization, WT-1 expression
patterns will be correlated with histological subtypes (epithelial,
fibrous, mixed) of mesotheliomas to determine if gene expression is
regulated by cell differentiation. 2) Identify alterations in the WT-1
gene in transformed rat mesothelial cells. Mutations at the WT-1 gene
locus will be identified in cell lines isolated from transformed rat
mesothelial cells (spontaneous and asbestos-induced) using direct
sequencing of PCR amplified CDNA. To gain information regarding the
function of WT-1 in transformed cells, rat mesothelioma cell lines will be
transfected with wild type WT-1 to determine the ability of this gene to
suppress the transformed phenotype. 3) Establish the similarity or
difference in WT-1 alterations between rat and human mesothelioma. Data
obtained from the rat cell lines will be expanded to primary rat tumors
induced by asbestos and human mesotheliomas to determine if WT-1 is a
putative target gene for asbestos. The usefulness of this gene as a
biomarker to discriminate between mesothelioma and parenchymal lung tumors
will be determined by examining the pattern of expression/alterations in
the WT-1 gene in other types of human lung cancer. Information resulting
from this research will yield new diagnostic strategies for the
identification of mesothelioma and yield mechanistic insights on the role
of the WT-1 suppressor gene as a putative gene target for asbestos in
mesothelioma development. In addition, these studies will contribute to
our knowledge regarding the WT-1 locus by elucidating the function of this
gene in an extra-renal neoplasm.
Tags: Wilms' Tumor, Asbestos, Environment Related Neoplasm /cancer, Mesothelioma, Tumor Suppressor Gene Biomarker, Cell Differentiation, Cell Transformation, Gene Mutation, Genetic Marker, Lung Neoplasm, Molecular Oncology, Neoplasm /cancer Diagnosis, Neoplasm /cancer Genetics, Nucleic Acid Sequence Human Tissue, In Situ Hybridization, Laboratory Mouse, Laboratory Rat, Polymerase Chain Reaction, Tissue /cell Culture
Tags: Wilms' Tumor, Asbestos, Environment Related Neoplasm /cancer, Mesothelioma, Tumor Suppressor Gene Biomarker, Cell Differentiation, Cell Transformation, Gene Mutation, Genetic Marker, Lung Neoplasm, Molecular Oncology, Neoplasm /cancer Diagnosis, Neoplasm /cancer Genetics, Nucleic Acid Sequence Human Tissue, In Situ Hybridization, Laboratory Mouse, Laboratory Rat, Polymerase Chain Reaction, Tissue /cell Culture
Walker, Cheryl L. Wilm's Tumor Suppressor Gene In Mesothelioma
Grant: 5R01ES006658-02
Grant: 5R01ES006658-02
Abstract: Mesothelioma is an asbestos associated tumor arising from mesothelial cells
that line the body cavities.
Although the etiology of asbestos induced mesothelioma has been well
described, very little is known about the molecular alterations that cause
these tumors. Our lack of knowledge regarding the molecular events that
cause mesothelioma has hampered efforts to identify alternative fibers that
can be used as safe asbestos substitutes and has contributed to a
diagnostic dilemma in the identification of these tumors. The long range
goal of this research is to understand how asbestos fibers transform
mesothelial cells. To achieve this goal, the general approach is to
identify molecular alterations that occur in transformed mesothelial cells
and elucidate the mechanism by which asbestos fibers caused these
alterations. The proposed studies are designed to determine the role of
the Wilms' tumor (WT-1) suppressor gene in normal and malignant mesothelial
cells. Specific Aims are to 1) Determine the expression pattern of the WT
1 gene in normal and transformed rat mesothelial cells. The expression of
the 4 splice variants of WT-1 in normal and transformed mesothelial cells
will be examined by PCR to identify differences in gene processing between
normal and transformed cells. Using in situ hybridization, WT-1 expression
patterns will be correlated with histological subtypes (epithelial,
fibrous, mixed) of mesotheliomas to determine if gene expression is
regulated by cell differentiation. 2) Identify alterations in the WT-1
gene in transformed rat mesothelial cells. Mutations at the WT-1 gene
locus will be identified in cell lines isolated from transformed rat
mesothelial cells (spontaneous and asbestos-induced) using direct
sequencing of PCR amplified CDNA. To gain information regarding the
function of WT-1 in transformed cells, rat mesothelioma cell lines will be
transfected with wild type WT-1 to determine the ability of this gene to
suppress the transformed phenotype. 3) Establish the similarity or
difference in WT-1 alterations between rat and human mesothelioma. Data
obtained from the rat cell lines will be expanded to primary rat tumors
induced by asbestos and human mesotheliomas to determine if WT-1 is a
putative target gene for asbestos. The usefulness of this gene as a
biomarker to discriminate between mesothelioma and parenchymal lung tumors
will be determined by examining the pattern of expression/alterations in
the WT-1 gene in other types of human lung cancer. Information resulting
from this research will yield new diagnostic strategies for the
identification of mesothelioma and yield mechanistic insights on the role
of the WT-1 suppressor gene as a putative gene target for asbestos in
mesothelioma development. In addition, these studies will contribute to
our knowledge regarding the WT-1 locus by elucidating the function of this
gene in an extra-renal neoplasm.
Tags: Wilms' Tumor, Asbestos, Environment Related Neoplasm /cancer, Mesothelioma, Tumor Suppressor Gene Biomarker, Cell Differentiation, Cell Transformation, Gene Mutation, Genetic Marker, Lung Neoplasm, Molecular Oncology, Neoplasm /cancer Diagnosis, Neoplasm /cancer Genetics, Nucleic Acid Sequence Gene Targeting, Human Tissue, In Situ Hybridization, Laboratory Mouse, Laboratory Rat, Polymerase Chain Reaction, Tissue /cell Culture
Tags: Wilms' Tumor, Asbestos, Environment Related Neoplasm /cancer, Mesothelioma, Tumor Suppressor Gene Biomarker, Cell Differentiation, Cell Transformation, Gene Mutation, Genetic Marker, Lung Neoplasm, Molecular Oncology, Neoplasm /cancer Diagnosis, Neoplasm /cancer Genetics, Nucleic Acid Sequence Gene Targeting, Human Tissue, In Situ Hybridization, Laboratory Mouse, Laboratory Rat, Polymerase Chain Reaction, Tissue /cell Culture
- Followup Grant: 5R01ES006658-04
- Followup Grant: 5R01ES006658-03
Bright, Robert K. T Cell Focused Cancer Vaccines In Murine Tumor Models
Grant: 7R29CA077351-06
Grant: 7R29CA077351-06
Abstract: DESCRIPTION: (Applicant's Abstract) One in six people will die of cancer.
the systemic nature, recall ability and exquisite specificity of the immune
system makes immunotherapy an attractive prospect for cancer treatment.
Hepatocellular carcinoma, cervical carcinoma, various leukemias and
lymphomas all have proposed viral etiologies. Viral encoded tumor specific
antigens make viral associated tumors strong candidates for immunotherapy.
Recent studies have described the presence of simian virus 40 (SV40)-like
gene sequences and proteins (specifically the large tumor antigen: SV40
Tag) in human osteosarcomas, glioblastomas, ependymomas and malignant
pleural mesotheliomas (MPM), demonstrating SV40 association with certain
human malignancies. To facilitate the development of human clinical
protocols for the immunotherapy of SV40 associated human malignancies, the
proposed study will employ an SV40 murine tumor system to evaluate the
efficacy of CTL transfer therapies and peptide based vaccines designed to
target an immune response to SV40 Tag expressing tumors in vivo. Briefly,
SV40 Tag specific CTL will be generated by immunization of Balb/c mice with
SV40 Tag gene constructs and the epitope specificity determined by using
selected H-2d restricted synthetic peptides representing potential CTL
epitopes on SV40 Tag. These CTL will be utilized to examine the ability of
adoptively transferred T cells to protect against tumor challenge in
syngeneic mice. Further, selected synthetic peptides will be examined for
the ability to actively induce protective tumor immunity in vivo.
Completion of this study will provide valuable information on the active
induction of tumor destructive immunity involving SV40 Tag-epitope specific
CTL in vivo. Moreover, the information generated using the murine SV40
tumor model will expedite the development of reagents and clinical trials
designed to examine SV40 Tag specific immunotherapies for SV40 associated
human malignancies.
Tags: Cytotoxic T Lymphocyte, Neoplasm /cancer Immunology, Neoplasm /cancer Immunotherapy, Neoplasm /cancer Vaccine, Nonhuman Therapy Evaluation, Simian Virus 40, Tumor Antigen Mhc Class I Antigen, Astrocytoma, Disease /disorder Model, Drug Screening /evaluation, Ependymoma, Immunogenetics, Mesothelioma, Neoplastic Cell, Neoplastic Transformation, Osteosarcoma, Synthetic Peptide, Virus Antigen, Virus Genetics, Virus Protein, Virus Related Neoplasm /cancer Active Immunization, Laboratory Mouse
Tags: Cytotoxic T Lymphocyte, Neoplasm /cancer Immunology, Neoplasm /cancer Immunotherapy, Neoplasm /cancer Vaccine, Nonhuman Therapy Evaluation, Simian Virus 40, Tumor Antigen Mhc Class I Antigen, Astrocytoma, Disease /disorder Model, Drug Screening /evaluation, Ependymoma, Immunogenetics, Mesothelioma, Neoplastic Cell, Neoplastic Transformation, Osteosarcoma, Synthetic Peptide, Virus Antigen, Virus Genetics, Virus Protein, Virus Related Neoplasm /cancer Active Immunization, Laboratory Mouse
Coltman, Charles A. Southwest Oncology Group--operations Office
Grant: 2U10CA032102-08
Grant: 2U10CA032102-08
Abstract: The Southwest Oncology Group is a major multidisease,
multidisciplinary cooperative therapeutic research organization
with 29 Member Institutions, 22 Community Clinical Oncology
Programs (CCOPs) and 148 Cooperative Group Outreach Program
(CGOP) Centers throughout the country. The scientific thrust of
the Group is through multidisciplinary disease oriented
committees which develop important, testable hypotheses in the
management of each tumor category. The Group is a powerful
tool in the design and conduct of innovative therapeutic research.
The long-term objective is improved treatment and potential cure
of many currently incurable malignancies.
This Competative Renewal Application differs from past
applications in that the Southwest Oncology Group has developed
a series of new initiatives designed to enhance urological cancer
research, and melanoma research as well as to extend the
scientific thrust of the Group from the basic science standpoint in
leukemia, lymphoma and flow cytometry of many tumor
categories.
Tags: Blood And Re System, Bone Marrow Transplantation, Neoplasms Of Blood And Re System, Leukemia Acute, Neoplasms Of Blood And Re System, Lymphoma, Neoplasms Of Body Regions, Head And Neck, Neoplasms Of Reproductive System, Breast Neoplasms, Neoplasms Of Respiratory System, Lung Neoplasms, Neoplasms Of Skin, Melanoma, Neoplasms, Pediatric, Neoplastic Therapy, Cancer Chemotherapy, Neoplastic Therapy, Cancer Radiotherapy Adrenal Cortex Hormones Analogs, Dexamethasone, Adrenal Cortex Hormones Analogs, Prednisone, Alkaloids, Vincristine, Antibiotics, Anthracyclines, Daunomycin, Antibiotics, Mithramycin, Antibiotics, Mitomycin C, Antineoplastic Agents, Antineoplastic Agents, Biological Response Modifiers, Aziridines, Bacteria, Actinomycetales, Bacillus Calmette-guerin, Benzo-alpha-pyrones, Cell Sorting, Laser, Children, Congenital Abnormalities, Skin, Nevus, Drugs Adverse Effects, Drugs Resistance, Drugs, Chemotherapy, Drugs Combination, Estratriene Series, Estrogens, Genetics, Cytogenetics, Genetics, Genes, Gene Amplification, Genetics, Genes, Gene Expression, Genetics, Genes, Proto-oncogenes, Genetics, Mutation, Chromosome Mutation, Chromosome Translocations, Guanidines, Cimetidine, Haloalkylamines, Bcnu, Haloalkylamines, Cyclophosphamide, Halopyrimidines, Halouracil, Fluorouracil, Immunity, Cytokines, Lymphokines, Interferons, Immunity, Cytokines, Lymphokines, Interleukin 2, Information Gathering (data Collection), Metals, Heavy Metals, Platinum (compounds), Cis Platinum Compounds, Neoplasms Classification And Staging, Neoplasms Diagnosis, Immunodiagnosis Of Neoplasms, Neoplasms Immunization (immunotherapy), Neoplasms Immunology, Tumor Antigens, Neoplasms Of Blood And Re System, Bone Marrow Neoplasms, Multiple Myeloma, Neoplasms Of Blood And Re System, Leukemia Chronic, Neoplasms Of Blood And Re System, Leukemia Lymphocytic, Neoplasms Of Blood And Re System, Leukemia Myeloid, Neoplasms Of Blood And Re System, Leukemia, Hairy T-cell Leukemia, Neoplasms Of Body Cavities, Mesothelioma, Neoplasms Of Brain, Neoplasms Of Gastrointestinal System, Neoplasms Of Nervous System, Glioma, Astrocytoma, Neoplasms Of Reproductive System Female, Neoplasms Of Reproductive System Female, Ovary Neoplasms, Neoplasms Of Reproductive System Female, Uterus Neoplasms, Neoplasms Of Reproductive System Female, Uterus Neoplasms, Cervix Neoplasms, Neoplasms Of Reproductive System Male, Prostate Neoplasms, Neoplasms Of Reproductive System Male, Testis Neoplasms, Neoplasms Of Skeletal System, Osteogenic Sarcoma, Neoplasms Of Urinary Tract, Kidney Neoplasms, Neoplasms Of Urinary Tract, Urinary Bladder Neoplasms, Neoplasms Surgery, Neoplasms, Sarcoma, Neoplastic Therapy, Combination Antineoplastic Therapy, Nucleic Acids, Mrna, Nursing, Nursing Care, Oncology Nursing, Pyrimidine Nucleosides, Cytosine Nucleosides, Cytosine Arabinoside, Radiation Therapy, Extracorporeal Radiation, Reproductive System Disorders Male, Penile Disorders, Therapy Evaluation, Human, Tissue (cell) Culture, Clone Cells, Tissue Compatibility-transplant, Transplantation Autologous, Cooperative Study Human, Clinical, Nucleic Acids, Nucleic Acid Probes
Tags: Blood And Re System, Bone Marrow Transplantation, Neoplasms Of Blood And Re System, Leukemia Acute, Neoplasms Of Blood And Re System, Lymphoma, Neoplasms Of Body Regions, Head And Neck, Neoplasms Of Reproductive System, Breast Neoplasms, Neoplasms Of Respiratory System, Lung Neoplasms, Neoplasms Of Skin, Melanoma, Neoplasms, Pediatric, Neoplastic Therapy, Cancer Chemotherapy, Neoplastic Therapy, Cancer Radiotherapy Adrenal Cortex Hormones Analogs, Dexamethasone, Adrenal Cortex Hormones Analogs, Prednisone, Alkaloids, Vincristine, Antibiotics, Anthracyclines, Daunomycin, Antibiotics, Mithramycin, Antibiotics, Mitomycin C, Antineoplastic Agents, Antineoplastic Agents, Biological Response Modifiers, Aziridines, Bacteria, Actinomycetales, Bacillus Calmette-guerin, Benzo-alpha-pyrones, Cell Sorting, Laser, Children, Congenital Abnormalities, Skin, Nevus, Drugs Adverse Effects, Drugs Resistance, Drugs, Chemotherapy, Drugs Combination, Estratriene Series, Estrogens, Genetics, Cytogenetics, Genetics, Genes, Gene Amplification, Genetics, Genes, Gene Expression, Genetics, Genes, Proto-oncogenes, Genetics, Mutation, Chromosome Mutation, Chromosome Translocations, Guanidines, Cimetidine, Haloalkylamines, Bcnu, Haloalkylamines, Cyclophosphamide, Halopyrimidines, Halouracil, Fluorouracil, Immunity, Cytokines, Lymphokines, Interferons, Immunity, Cytokines, Lymphokines, Interleukin 2, Information Gathering (data Collection), Metals, Heavy Metals, Platinum (compounds), Cis Platinum Compounds, Neoplasms Classification And Staging, Neoplasms Diagnosis, Immunodiagnosis Of Neoplasms, Neoplasms Immunization (immunotherapy), Neoplasms Immunology, Tumor Antigens, Neoplasms Of Blood And Re System, Bone Marrow Neoplasms, Multiple Myeloma, Neoplasms Of Blood And Re System, Leukemia Chronic, Neoplasms Of Blood And Re System, Leukemia Lymphocytic, Neoplasms Of Blood And Re System, Leukemia Myeloid, Neoplasms Of Blood And Re System, Leukemia, Hairy T-cell Leukemia, Neoplasms Of Body Cavities, Mesothelioma, Neoplasms Of Brain, Neoplasms Of Gastrointestinal System, Neoplasms Of Nervous System, Glioma, Astrocytoma, Neoplasms Of Reproductive System Female, Neoplasms Of Reproductive System Female, Ovary Neoplasms, Neoplasms Of Reproductive System Female, Uterus Neoplasms, Neoplasms Of Reproductive System Female, Uterus Neoplasms, Cervix Neoplasms, Neoplasms Of Reproductive System Male, Prostate Neoplasms, Neoplasms Of Reproductive System Male, Testis Neoplasms, Neoplasms Of Skeletal System, Osteogenic Sarcoma, Neoplasms Of Urinary Tract, Kidney Neoplasms, Neoplasms Of Urinary Tract, Urinary Bladder Neoplasms, Neoplasms Surgery, Neoplasms, Sarcoma, Neoplastic Therapy, Combination Antineoplastic Therapy, Nucleic Acids, Mrna, Nursing, Nursing Care, Oncology Nursing, Pyrimidine Nucleosides, Cytosine Nucleosides, Cytosine Arabinoside, Radiation Therapy, Extracorporeal Radiation, Reproductive System Disorders Male, Penile Disorders, Therapy Evaluation, Human, Tissue (cell) Culture, Clone Cells, Tissue Compatibility-transplant, Transplantation Autologous, Cooperative Study Human, Clinical, Nucleic Acids, Nucleic Acid Probes
- Followup Grant: 5U10CA032102-09
- Followup Grant: 5U10CA032102-10
Coltman, Charles A. Southwest Oncology Group - Operations Office
Grant: 5U10CA032102-11
Grant: 5U10CA032102-11
Abstract: The Southwest Oncology Group is a major multidisease,
multidisciplinary cooperative therapeutic research organization
with 29 Member Institutions, 22 Community Clinical Oncology
Programs (CCOPs) and 148 Cooperative Group Outreach Program
(CGOP) Centers throughout the country. The scientific thrust of
the Group is through multidisciplinary disease oriented
committees which develop important, testable hypotheses in the
management of each tumor category. The Group is a powerful
tool in the design and conduct of innovative therapeutic research.
The long-term objective is improved treatment and potential cure
of many currently incurable malignancies.
This Competative Renewal Application differs from past
applications in that the Southwest Oncology Group has developed
a series of new initiatives designed to enhance urological cancer
research, and melanoma research as well as to extend the
scientific thrust of the Group from the basic science standpoint in
leukemia, lymphoma and flow cytometry of many tumor
categories.
Tags: Acute Leukemia, Acute Lymphoblastic Leukemia, Bone Marrow Transplantation, Breast Neoplasm, Head /neck Neoplasm, Lung Neoplasm, Lymphoma, Melanoma, Neoplasm /cancer Chemotherapy, Neoplasm /cancer Radiation Therapy, Pediatric Neoplasm /cancer Bacillus Calmette Guerin, Alpha Benzopyrone, Antineoplastic, Astrocytoma, Autologous Transplantation, Aziridine, Biological Response Modifier, Bladder Neoplasm, Brain Neoplasm, Carmustine, Cervix Neoplasm, Child (0-20), Chromosome Translocation, Chronic Leukemia, Cimetidine, Cis Platinum Compound, Clone Cell, Combination Antineoplastic Therapy, Combination Chemotherapy, Cooperative Study, Cyclophosphamide, Cytogenetics, Cytosine Arabinoside, Data Collection, Daunorubicin, Dexamethasone, Drug Adverse Effect, Drug Resistance, Estrogen, Extracorporeal Radiation, Female Reproductive System Neoplasm, Fluorescence Activated Cell Sorter, Fluorouracil, Gastrointestinal Neoplasm, Gene Amplification, Gene Expression, Hairy T Cell Leukemia, Human Therapy Evaluation, Interferon, Interleukin 2, Kidney Neoplasm, Lymphocytic Leukemia, Mesothelioma, Messenger Rna, Mithramycin, Mitomycin C, Multiple Myeloma, Myeloid Leukemia, Neoplasm /cancer Classification /staging, Neoplasm /cancer Immunodiagnosis, Neoplasm /cancer Immunotherapy, Neoplasm /cancer Surgery, Nevus, Oncology Nursing, Osteogenic Sarcoma, Ovary Neoplasm, Penis Disorder, Prednisone, Prostate Neoplasm, Protooncogene, Sarcoma, Testis Neoplasm, Tumor Antigen, Uterus Neoplasm, Vincristine Human Clinical Subject, Nucleic Acid Probe
Tags: Acute Leukemia, Acute Lymphoblastic Leukemia, Bone Marrow Transplantation, Breast Neoplasm, Head /neck Neoplasm, Lung Neoplasm, Lymphoma, Melanoma, Neoplasm /cancer Chemotherapy, Neoplasm /cancer Radiation Therapy, Pediatric Neoplasm /cancer Bacillus Calmette Guerin, Alpha Benzopyrone, Antineoplastic, Astrocytoma, Autologous Transplantation, Aziridine, Biological Response Modifier, Bladder Neoplasm, Brain Neoplasm, Carmustine, Cervix Neoplasm, Child (0-20), Chromosome Translocation, Chronic Leukemia, Cimetidine, Cis Platinum Compound, Clone Cell, Combination Antineoplastic Therapy, Combination Chemotherapy, Cooperative Study, Cyclophosphamide, Cytogenetics, Cytosine Arabinoside, Data Collection, Daunorubicin, Dexamethasone, Drug Adverse Effect, Drug Resistance, Estrogen, Extracorporeal Radiation, Female Reproductive System Neoplasm, Fluorescence Activated Cell Sorter, Fluorouracil, Gastrointestinal Neoplasm, Gene Amplification, Gene Expression, Hairy T Cell Leukemia, Human Therapy Evaluation, Interferon, Interleukin 2, Kidney Neoplasm, Lymphocytic Leukemia, Mesothelioma, Messenger Rna, Mithramycin, Mitomycin C, Multiple Myeloma, Myeloid Leukemia, Neoplasm /cancer Classification /staging, Neoplasm /cancer Immunodiagnosis, Neoplasm /cancer Immunotherapy, Neoplasm /cancer Surgery, Nevus, Oncology Nursing, Osteogenic Sarcoma, Ovary Neoplasm, Penis Disorder, Prednisone, Prostate Neoplasm, Protooncogene, Sarcoma, Testis Neoplasm, Tumor Antigen, Uterus Neoplasm, Vincristine Human Clinical Subject, Nucleic Acid Probe
Coltman, Charles A. Southwest Oncology Group--ccop Research Base
Grant: 2U10CA037429-07
Grant: 2U10CA037429-07
Abstract: The Southwest Oncology Group is a major multi-disease, multi-disciplinary
cooperative group organization, which includes 36 Member Institutions, 25
Community Clinical Oncology Programs (CCOPs), and 265 Cooperative Group
Outreach Program affiliates (CGOPs) centered throughout the United States
and Canada. New program initiatives have brought on 25 Urologic Cancer
Oncology Program (UCOP) affiliates and 34 High Priority participants to add
to the Group's total annual accrual of approximately 7000 patients. this
Competitive Renewal Application is submitted to fund the Southwest Oncology
Group as a research base for the current and proposed Community Clinical
Oncology Program participants. Significant components of this application
include a major emphasis of this cooperative group to increase minority
participation in clinical trials through the addition of seven Minority-
based CCOPs and the formation of a Minorities Subcommittee in the Cancer
Control Research Committee. The Southwest Oncology Group also continues to
promote and strengthen its internationally-known expertise in cancer
control and prevention research through the efforts of the Cancer Control
Research Committee, particularly in the areas of quality of life and
chemoprevention.
Tags: Cancer Information System, Cancer Prevention, Cancer Rehabilitation /care, Community Health Service, Health Science Research Analysis /evaluation, Human Therapy Evaluation, Neoplasm /cancer Education, Neoplasm /cancer Therapy, Patient Care Planning 13 Cis Retinoate, Cns Neoplasm, Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Androgen Inhibitor, Antineoplastic, Autologous Transplantation, Bladder Neoplasm, Bleomycin, Bone Marrow Transplantation, Breast Neoplasm, Cancer Registry /resource, Carcinogenesis Inhibitor, Carmustine, Cervix Neoplasm, Chronic Leukemia, Cis Platinum Compound, Clinical Study /trial, Colon Neoplasm, Colorectal Neoplasm, Combination Antineoplastic Therapy, Combination Chemotherapy, Continuing Education, Cooperative Study, Cyclophosphamide, Cytosine Arabinoside, Diaziquone, Doxorubicin, Estrogen Receptor, Etoposide, Fluorouracil, Folate, Germ Cell Neoplasm, Glioma, Hairy T Cell Leukemia, Head /neck Neoplasm, Homologous Transplantation, Ifosfamide, Interferon, Interleukin 2, Isoquinoline, Kidney Neoplasm, Lomustine, Lung Neoplasm, Lymphoma, Male Reproductive System Neoplasm, Mechlorethamine, Melanoma, Mesothelioma, Metastasis, Methotrexate, Multiple Myeloma, Mycosis Fungoides Lymphoma, Neoplasm /cancer Chemotherapy, Neoplasm /cancer Hormone Therapy, Neoplasm /cancer Immunotherapy, Neoplasm /cancer Nutrition Therapy, Neoplasm /cancer Radiation Therapy, Oat Cell Carcinoma, Ovary Neoplasm, Pancreas Neoplasm, Patient /disease Registry, Peptide Hormone Analog, Platinum, Prednisone, Procarbazine, Prostate Neoplasm, Quality Of Life, Reproductive System Neoplasm, Tamoxifen, Testis Neoplasm, Tumor Necrosis Factor Alpha, Uterus Neoplasm, Vincristine Human Clinical Subject
Tags: Cancer Information System, Cancer Prevention, Cancer Rehabilitation /care, Community Health Service, Health Science Research Analysis /evaluation, Human Therapy Evaluation, Neoplasm /cancer Education, Neoplasm /cancer Therapy, Patient Care Planning 13 Cis Retinoate, Cns Neoplasm, Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Androgen Inhibitor, Antineoplastic, Autologous Transplantation, Bladder Neoplasm, Bleomycin, Bone Marrow Transplantation, Breast Neoplasm, Cancer Registry /resource, Carcinogenesis Inhibitor, Carmustine, Cervix Neoplasm, Chronic Leukemia, Cis Platinum Compound, Clinical Study /trial, Colon Neoplasm, Colorectal Neoplasm, Combination Antineoplastic Therapy, Combination Chemotherapy, Continuing Education, Cooperative Study, Cyclophosphamide, Cytosine Arabinoside, Diaziquone, Doxorubicin, Estrogen Receptor, Etoposide, Fluorouracil, Folate, Germ Cell Neoplasm, Glioma, Hairy T Cell Leukemia, Head /neck Neoplasm, Homologous Transplantation, Ifosfamide, Interferon, Interleukin 2, Isoquinoline, Kidney Neoplasm, Lomustine, Lung Neoplasm, Lymphoma, Male Reproductive System Neoplasm, Mechlorethamine, Melanoma, Mesothelioma, Metastasis, Methotrexate, Multiple Myeloma, Mycosis Fungoides Lymphoma, Neoplasm /cancer Chemotherapy, Neoplasm /cancer Hormone Therapy, Neoplasm /cancer Immunotherapy, Neoplasm /cancer Nutrition Therapy, Neoplasm /cancer Radiation Therapy, Oat Cell Carcinoma, Ovary Neoplasm, Pancreas Neoplasm, Patient /disease Registry, Peptide Hormone Analog, Platinum, Prednisone, Procarbazine, Prostate Neoplasm, Quality Of Life, Reproductive System Neoplasm, Tamoxifen, Testis Neoplasm, Tumor Necrosis Factor Alpha, Uterus Neoplasm, Vincristine Human Clinical Subject
- Followup Grant: 5U10CA037429-08
Coltman, Charles A. Southwest Oncology Group-ccop Research Base
Grant: 5U10CA037429-09
Grant: 5U10CA037429-09
Abstract: The Southwest Oncology Group is a major multi-disease, multi-disciplinary
cooperative group organization, which includes 36 Member Institutions, 25
Community Clinical Oncology Programs (CCOPs), and 265 Cooperative Group
Outreach Program affiliates (CGOPs) centered throughout the United States
and Canada. New program initiatives have brought on 25 Urologic Cancer
Oncology Program (UCOP) affiliates and 34 High Priority participants to add
to the Group's total annual accrual of approximately 7000 patients. this
Competitive Renewal Application is submitted to fund the Southwest Oncology
Group as a research base for the current and proposed Community Clinical
Oncology Program participants. Significant components of this application
include a major emphasis of this cooperative group to increase minority
participation in clinical trials through the addition of seven Minority-
based CCOPs and the formation of a Minorities Subcommittee in the Cancer
Control Research Committee. The Southwest Oncology Group also continues to
promote and strengthen its internationally-known expertise in cancer
control and prevention research through the efforts of the Cancer Control
Research Committee, particularly in the areas of quality of life and
chemoprevention.
Tags: Cancer Information System, Cancer Rehabilitation /care, Community Health Service, Health Science Research Analysis /evaluation, Human Therapy Evaluation, Neoplasm /cancer Education, Neoplasm /cancer Therapy, Patient Care Planning 13 Cis Retinoate, Cns Neoplasm, Acute Leukemia, Acute Lymphocytic Leukemia, Acute Myelogenous Leukemia, Androgen Inhibitor, Antineoplastic, Autologous Transplantation, Bladder Neoplasm, Bleomycin, Bone Marrow Transplantation, Breast Neoplasm, Cancer Registry /resource, Carcinogenesis Inhibitor, Carmustine, Cervix Neoplasm, Chemoprevention, Chronic Leukemia, Cis Platinum Compound, Clinical Study /trial, Colon Neoplasm, Colorectal Neoplasm, Combination Antineoplastic Therapy, Combination Chemotherapy, Continuing Education, Cooperative Study, Cyclophosphamide, Cytosine Arabinoside, Diaziquone, Doxorubicin, Estrogen Receptor, Etoposide, Fluorouracil, Folate, Germ Cell Neoplasm, Glioma, Hairy T Cell Leukemia, Head /neck Neoplasm, Homologous Transplantation, Hormone Therapy, Ifosfamide, Interferon, Interleukin 2, Isoquinoline, Kidney Neoplasm, Lomustine, Lung Neoplasm, Lymphoma, Male Reproductive System Neoplasm, Mechlorethamine, Melanoma, Mesothelioma, Metastasis, Methotrexate, Multiple Myeloma, Mycosis Fungoides Lymphoma, Neoplasm /cancer Chemotherapy, Neoplasm /cancer Immunotherapy, Neoplasm /cancer Nutrition Therapy, Neoplasm /cancer Radiation Therapy, Ovary Neoplasm, Pancreas Neoplasm, Patient /disease Registry, Peptide Hormone Analog, Platinum, Prednisone, Procarbazine, Prostate Neoplasm, Quality Of Life, Reproductive System Neoplasm, Small Cell Carcinoma Of Lung, Tamoxifen, Testis Neoplasm, Tumor Necrosis Factor Alpha, Uterus Neoplasm, Vincristine Human Subject, Nutrition Related Tag
Tags: Cancer Information System, Cancer Rehabilitation /care, Community Health Service, Health Science Research Analysis /evaluation, Human Therapy Evaluation, Neoplasm /cancer Education, Neoplasm /cancer Therapy, Patient Care Planning 13 Cis Retinoate, Cns Neoplasm, Acute Leukemia, Acute Lymphocytic Leukemia, Acute Myelogenous Leukemia, Androgen Inhibitor, Antineoplastic, Autologous Transplantation, Bladder Neoplasm, Bleomycin, Bone Marrow Transplantation, Breast Neoplasm, Cancer Registry /resource, Carcinogenesis Inhibitor, Carmustine, Cervix Neoplasm, Chemoprevention, Chronic Leukemia, Cis Platinum Compound, Clinical Study /trial, Colon Neoplasm, Colorectal Neoplasm, Combination Antineoplastic Therapy, Combination Chemotherapy, Continuing Education, Cooperative Study, Cyclophosphamide, Cytosine Arabinoside, Diaziquone, Doxorubicin, Estrogen Receptor, Etoposide, Fluorouracil, Folate, Germ Cell Neoplasm, Glioma, Hairy T Cell Leukemia, Head /neck Neoplasm, Homologous Transplantation, Hormone Therapy, Ifosfamide, Interferon, Interleukin 2, Isoquinoline, Kidney Neoplasm, Lomustine, Lung Neoplasm, Lymphoma, Male Reproductive System Neoplasm, Mechlorethamine, Melanoma, Mesothelioma, Metastasis, Methotrexate, Multiple Myeloma, Mycosis Fungoides Lymphoma, Neoplasm /cancer Chemotherapy, Neoplasm /cancer Immunotherapy, Neoplasm /cancer Nutrition Therapy, Neoplasm /cancer Radiation Therapy, Ovary Neoplasm, Pancreas Neoplasm, Patient /disease Registry, Peptide Hormone Analog, Platinum, Prednisone, Procarbazine, Prostate Neoplasm, Quality Of Life, Reproductive System Neoplasm, Small Cell Carcinoma Of Lung, Tamoxifen, Testis Neoplasm, Tumor Necrosis Factor Alpha, Uterus Neoplasm, Vincristine Human Subject, Nutrition Related Tag
Coltman, Charles A. Southwest Oncology Group Coop Research Base
Grant: 5U10CA037429-10
Grant: 5U10CA037429-10
Abstract: The Southwest Oncology Group is a major multi-disease, multi-disciplinary
cooperative group organization, which includes 36 Member Institutions, 25
Community Clinical Oncology Programs (CCOPs), and 265 Cooperative Group
Outreach Program affiliates (CGOPs) centered throughout the United States
and Canada. New program initiatives have brought on 25 Urologic Cancer
Oncology Program (UCOP) affiliates and 34 High Priority participants to add
to the Group's total annual accrual of approximately 7000 patients. this
Competitive Renewal Application is submitted to fund the Southwest Oncology
Group as a research base for the current and proposed Community Clinical
Oncology Program participants. Significant components of this application
include a major emphasis of this cooperative group to increase minority
participation in clinical trials through the addition of seven Minority-
based CCOPs and the formation of a Minorities Subcommittee in the Cancer
Control Research Committee. The Southwest Oncology Group also continues to
promote and strengthen its internationally-known expertise in cancer
control and prevention research through the efforts of the Cancer Control
Research Committee, particularly in the areas of quality of life and
chemoprevention.
Tags: Cancer Information System, Cancer Rehabilitation /care, Community Health Service, Health Science Research Analysis /evaluation, Human Therapy Evaluation, Neoplasm /cancer Education, Neoplasm /cancer Therapy, Patient Care Planning 13 Cis Retinoate, Cns Neoplasm, Acute Leukemia, Acute Lymphocytic Leukemia, Acute Myelogenous Leukemia, Androgen Inhibitor, Antineoplastic, Autologous Transplantation, Bladder Neoplasm, Bleomycin, Bone Marrow Transplantation, Breast Neoplasm, Cancer Registry /resource, Carcinogenesis Inhibitor, Carmustine, Cervix Neoplasm, Chemoprevention, Chronic Leukemia, Cis Platinum Compound, Clinical Trial, Colon Neoplasm, Colorectal Neoplasm, Combination Antineoplastic Therapy, Combination Chemotherapy, Continuing Education, Cooperative Study, Cyclophosphamide, Cytosine Arabinoside, Diaziquone, Doxorubicin, Estrogen Receptor, Etoposide, Fluorouracil, Folate, Germ Cell Neoplasm, Glioma, Hairy T Cell Leukemia, Head /neck Neoplasm, Homologous Transplantation, Hormone Therapy, Ifosfamide, Interferon, Interleukin 2, Isoquinoline, Kidney Neoplasm, Lomustine, Lung Neoplasm, Lymphoma, Male Reproductive System Neoplasm, Mechlorethamine, Melanoma, Mesothelioma, Metastasis, Methotrexate, Multiple Myeloma, Mycosis Fungoides Lymphoma, Neoplasm /cancer Chemotherapy, Neoplasm /cancer Immunotherapy, Neoplasm /cancer Nutrition Therapy, Neoplasm /cancer Radiation Therapy, Ovary Neoplasm, Pancreas Neoplasm, Patient /disease Registry, Peptide Hormone Analog, Platinum, Prednisone, Procarbazine, Prostate Neoplasm, Quality Of Life, Reproductive System Neoplasm, Small Cell Carcinoma Of Lung, Tamoxifen, Testis Neoplasm, Tumor Necrosis Factor Alpha, Uterus Neoplasm, Vincristine Human Subject, Nutrition Related Tag
Tags: Cancer Information System, Cancer Rehabilitation /care, Community Health Service, Health Science Research Analysis /evaluation, Human Therapy Evaluation, Neoplasm /cancer Education, Neoplasm /cancer Therapy, Patient Care Planning 13 Cis Retinoate, Cns Neoplasm, Acute Leukemia, Acute Lymphocytic Leukemia, Acute Myelogenous Leukemia, Androgen Inhibitor, Antineoplastic, Autologous Transplantation, Bladder Neoplasm, Bleomycin, Bone Marrow Transplantation, Breast Neoplasm, Cancer Registry /resource, Carcinogenesis Inhibitor, Carmustine, Cervix Neoplasm, Chemoprevention, Chronic Leukemia, Cis Platinum Compound, Clinical Trial, Colon Neoplasm, Colorectal Neoplasm, Combination Antineoplastic Therapy, Combination Chemotherapy, Continuing Education, Cooperative Study, Cyclophosphamide, Cytosine Arabinoside, Diaziquone, Doxorubicin, Estrogen Receptor, Etoposide, Fluorouracil, Folate, Germ Cell Neoplasm, Glioma, Hairy T Cell Leukemia, Head /neck Neoplasm, Homologous Transplantation, Hormone Therapy, Ifosfamide, Interferon, Interleukin 2, Isoquinoline, Kidney Neoplasm, Lomustine, Lung Neoplasm, Lymphoma, Male Reproductive System Neoplasm, Mechlorethamine, Melanoma, Mesothelioma, Metastasis, Methotrexate, Multiple Myeloma, Mycosis Fungoides Lymphoma, Neoplasm /cancer Chemotherapy, Neoplasm /cancer Immunotherapy, Neoplasm /cancer Nutrition Therapy, Neoplasm /cancer Radiation Therapy, Ovary Neoplasm, Pancreas Neoplasm, Patient /disease Registry, Peptide Hormone Analog, Platinum, Prednisone, Procarbazine, Prostate Neoplasm, Quality Of Life, Reproductive System Neoplasm, Small Cell Carcinoma Of Lung, Tamoxifen, Testis Neoplasm, Tumor Necrosis Factor Alpha, Uterus Neoplasm, Vincristine Human Subject, Nutrition Related Tag
Idell, Steven Control Of Fibrin Turnover In Pleural Disease
Grant: 1P01HL076406-01A10001
Grant: 1P01HL076406-01A10001
Abstract: Disordered fibrin turnover has been implicated in the pathogenesis of pleural inflammation and repair. We hypothesize that deranged regulation of plasminogen activator inhibitor-1 (PAI-1) and of the urokinase receptor (uPAR) in pleural mesothelial cells are critical determinants of locally impaired fibrinolysis and intrapleural remodeling after asbestos exposure or in fibrosing pleuritis. Mechanisms that regulate expression of these proteins in mesothelial cells are now poorly understood. We will extend work done in previous funding cycles to address these important gaps. We will achieve this objective in four closely integrated specific aims. In Aim 1, we will determine mechanisms that regulate the expression of PAI-1 and uPAR in mesothelial cells exposed to asbestos or mediators of fibrosing pleural injury. In Aims 2 and 3, we will elucidate mechanism(s) by which PAI-1 is regulated by pleural mesothelial cells at the posttranscriptional level and will determine how control at this level influences pathophysiologic responses of these cells. In Aim 4, we will further test a novel interventional approach; intrapleural administration of single-chain uPA (scuPA) to prevent pleural loculation. We will use our established rabbit models of tetracycline- or P. multocida induced pleural injury in these studies. To accomplish the work, we will use a wide range of molecular, biochemical and histologic techniques, all of which are well-established in our laboratory. These studies will foster better understanding of the role
of the mesothelial cell in the regulation of the PAI-1-uPA-uPAR system and will increase our
understanding of how these cells contribute to pleural remodeling after injury. The project will also facilitate the development of novel, clinically applicable non-surgical approaches to prevent intrapleural loculation and its associated morbidity.
Tags: Fibrin, Fibrinolysis, Lung Disorder, Pathologic Process, Plasminogen Activator Inhibitor, Pleural Cavity Effusion Rna Binding Protein, Mesothelioma, Posttranscriptional Rna Processing, Protein Binding, Protein Biosynthesis, Protein Protein Interaction, Receptor Expression, Urokinase Cell Line, Human Tissue, Immunocytochemistry
Tags: Fibrin, Fibrinolysis, Lung Disorder, Pathologic Process, Plasminogen Activator Inhibitor, Pleural Cavity Effusion Rna Binding Protein, Mesothelioma, Posttranscriptional Rna Processing, Protein Binding, Protein Biosynthesis, Protein Protein Interaction, Receptor Expression, Urokinase Cell Line, Human Tissue, Immunocytochemistry
- Followup Grant: 5P01HL076406-020001
- Followup Grant: 5P01HL076406-030001
- Followup Grant: 5P01HL076406-040001
Okayasu, Ryuichi Role Of Dna Repair In Asbestos Toxicity
Grant: 5R03CA071438-02
Grant: 5R03CA071438-02
Abstract: DESCRIPTION: (Applicant's Abstract) Although asbestos exposure causes
human disease such as asbestosis, lung carcinoma, and mesothelioma, the
mechanism of toxicity is not clearly understood. Abundant evidence
suggests that free radicals mediate its toxicity, the target of which,
however, is not clearly defined. The goal of this proposal is to
further clarify the cellular and molecular mechanisms of asbestos
toxicity and define a basis for the prevention of asbestos-related
diseases. This will be attained by an in vitro model system using a
unique DNA repair deficient mutant cell line. Two hypotheses to be
tested are 1) DNA double strand breaks (DSBs) produced by free radicals
play a critical role in asbestos induced toxicity; if DNA DSBs are not
repaired or misrepaired, cells are killed. 2) Reduction in initial DNA
damage by an antioxidant agent in asbestos treated cells results in
reduction of cytotoxicity. The following specific aims are proposed to
test these hypotheses. i) To investigate the effect of DNA DSB and
repair on cell survival using a DNA DSB repair deficient mutant of CHO
cells (xrs-5 cells) treated with asbestos fibers. Colony formation
assay will be employed in xrs-5 and CHO cells exposed to asbestos. ii)
To directly measure the degree of DNA DSBs in asbestos treated CHO and
xrs-5 cells by a pulsed-field gel electrophoresis. The premature
chromosome condensation technique which can detect interphase chromosome
breaks will be applied to further clarify the sequence of events from
DNA damage to cell death. iii) To examine the effect of an anti-oxidant
in asbestos induced cell killing and DNA DSBs using CHO cells. The cell
survival assay will be employed but with combined treatments of asbestos
and ascorbic acid. DNA DSBs will be examined with samples of the
combined treatments as in ii). All of these studies will be conducted
with chrysotile and crocidolite fibers (with higher iron content) to
examine the catalytic power of iron in crocidolites. The results from
these studies shall clarify the role of DNA damage/repair, specifically
DNA DSBs, in asbestos induced toxicity, and may provide a useful basis
for reducing the toxicity.
Tags: Dna Damage, Dna Repair, Asbestos, Cytotoxicity, Environmental Toxicology Antioxidant, Ascorbate, Free Radical Oxygen, Iron, Oxidative Stress Cho Cell, Mutant, Pulsed Field Gel Electrophoresis, Tissue /cell Culture
Tags: Dna Damage, Dna Repair, Asbestos, Cytotoxicity, Environmental Toxicology Antioxidant, Ascorbate, Free Radical Oxygen, Iron, Oxidative Stress Cho Cell, Mutant, Pulsed Field Gel Electrophoresis, Tissue /cell Culture
Van Houten, Bennett Asbestos Induced Oxidative Dna Damage And Repair
Grant: 1R01ES007038-01
Grant: 1R01ES007038-01
Abstract: There is no text on file for this abstract.
Tags: Dna Damage, Dna Repair, Asbestos, Chemical Carcinogenesis, Free Radical Oxygen Adduct, Antioxidant, Chemical Carcinogen, Fibroblast, Hypoxanthine Phosphoribosyltransferase, Mesothelioma, Mitochondrial Dna, Neoplasm /cancer Genetics, Nucleic Acid Sequence, Tumor Suppressor Gene, Xeroderma Pigmentosum Gas Chromatography Mass Spectrometry, High Performance Liquid Chromatography, Polymerase Chain Reaction
Tags: Dna Damage, Dna Repair, Asbestos, Chemical Carcinogenesis, Free Radical Oxygen Adduct, Antioxidant, Chemical Carcinogen, Fibroblast, Hypoxanthine Phosphoribosyltransferase, Mesothelioma, Mitochondrial Dna, Neoplasm /cancer Genetics, Nucleic Acid Sequence, Tumor Suppressor Gene, Xeroderma Pigmentosum Gas Chromatography Mass Spectrometry, High Performance Liquid Chromatography, Polymerase Chain Reaction
- Followup Grant: 5R01ES007038-02
- Followup Grant: 5R01ES007038-04
- Followup Grant: 5R01ES007038-05
Clinical Trials
Condition: Mesothelioma
Intervention: Drug: bevacizumab; Drug: cisplatin; Drug: pemetrexed
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Intervention: Drug: bevacizumab; Drug: cisplatin; Drug: pemetrexed
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Condition: Malignant Mesothelioma
Intervention: Drug: cisplatin; Drug: gemcitabine hydrochloride
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Intervention: Drug: cisplatin; Drug: gemcitabine hydrochloride
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Condition: Mesothelioma; Lung Cancer
Intervention: Drug: Comparator: Suberoylanilide Hydroxamic Acid (Vorinostat, MK0683); Drug: Comparator: Placebo
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Intervention: Drug: Comparator: Suberoylanilide Hydroxamic Acid (Vorinostat, MK0683); Drug: Comparator: Placebo
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Condition: Lung Cancer; Malignant Mesothelioma; Pancreatic Cancer; Sarcoma
Intervention: Drug: L-alanosine
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Intervention: Drug: L-alanosine
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Condition: Malignant Mesothelioma
Intervention: Biological: bevacizumab; Drug: cisplatin; Drug: gemcitabine hydrochloride
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Intervention: Biological: bevacizumab; Drug: cisplatin; Drug: gemcitabine hydrochloride
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Condition: Malignant Mesothelioma
Intervention: Drug: liposomal NDDP; Procedure: thoracoscopic surgery
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Intervention: Drug: liposomal NDDP; Procedure: thoracoscopic surgery
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Condition: Anal Cancer; Carcinoma of the Appendix; Colorectal Cancer; Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Gastric Cancer; Gastrointestinal Carcinoid Tumor; Malignant Mesothelioma; Pancreatic Cancer; Small Intestine Cancer
Intervention: Biological: recombinant interleukin-12
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Intervention: Biological: recombinant interleukin-12
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Condition: Mesothelioma
Intervention: Drug: Cisplatin; Drug: Imatinib Mesylate; Drug: Pemetrexed
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Intervention: Drug: Cisplatin; Drug: Imatinib Mesylate; Drug: Pemetrexed
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Condition: Malignant Pleural Mesothelioma; MPM; Solid Tumors
Intervention: Drug: pemetrexed, cisplatin and CBP501; Drug: pemetrexed and cisplatin
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Intervention: Drug: pemetrexed, cisplatin and CBP501; Drug: pemetrexed and cisplatin
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Condition: Malignant Mesothelioma
Intervention: Drug: antineoplaston A10; Drug: antineoplaston AS2-1
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Intervention: Drug: antineoplaston A10; Drug: antineoplaston AS2-1
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Condition: Cancer
Intervention: Drug: fentanyl sublingual spray; Other: questionnaire administration
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Intervention: Drug: fentanyl sublingual spray; Other: questionnaire administration
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Condition: Metastatic Non-squamous Non Small Cell Lung Cancer
Intervention: Drug: CBP501 + Cisplatin + Pemetrexed; Drug: Cisplatin + Pemetrexed
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Intervention: Drug: CBP501 + Cisplatin + Pemetrexed; Drug: Cisplatin + Pemetrexed
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